Macrolides
| Overview |
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- The macrolides are a class of structurally-related Bacterial Ribosome Inhibitors. These drugs are often used in patients who cannot tolerate penicillins due to allergies. These drugs are well-tolerated and result in relatively few adverse effects.
| Mechanism of Action |
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- Macrolides bind to the 50S subunit of the bacterial ribosome.
| Adverse Effects |
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- GI System: Can cause some gastric irritation resulting in epigastric pain
- Biliary Tree: Can result in cholestasis and thus jaundice
| Member Drugs |
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- Azithromycin
- Clarithromycin
- Erythromycin