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Viral Uncoating Inhibitors

Mechanism of Action
  • Successful uncoating of Influenza Virus requires the action of the M2 ion channel. Viral Uncoating Inhibitors interfere with the M2 ion channel and in doing so inhibit viral uncoating and thus infection of host cells.
Adverse Effects
  • These drugs are associated with some mild CNS adverse effects including insomnia and dizziness. Rarely, at high concentrations, seizures and hallucinations have been reported.
Member Drugs
  • Amantidine
  • Rimantidine