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Transplant Rejection

  • From an immunological perspective, Organ Transplantation results in a fascinating interplay between host and donor immune cells which mount responses toward one another. Without precise immunological matching between host and donor tissues, both Cell-mediated Immunity and Humoral Immunity can become activated, resulting in both host-mediated rejection of the transplanted organ and transplant-mediated rejection of host tissues. Various patterns of rejection have been identified which are operative at different timescales and highlight different immunological mechanisms of immune injury to donor or host tissues.
Rejection Subtypes