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  • Secretin is a peptide hormone secreted by S Cells of the duodenum of the small intestine and modulates pacreatic secretion.
Secretin Regulation
  • Reduced pH within the duodenum caused by the entry of stomach acid directly acts on S Cells to release secretin.
Secretin Actions
  • Secretin acts on the exocrine pancreas to induce pancreatic secretion of fluid and bicarbonate which helps neutralize the stomach acid within the small intestine. Pancreatic secretion of fluid also washes accumulated pancreatic enzymes into the small intestine as described in pancreatic secretion.