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Platelet Inhibitors

  • Platelet Inhibitors refer to a variety of drugs that inhibit the process of platelet aggregation, discussed in Platelet Plugging. Three basic categories of drugs can be identified based on their mechanism of action. Aspirin inhibits production of Thromboxane A2, the thienopyridines such as Clopidogrel inhibit binding of ADP to its receptors, while a variety of biologics inhibit the GPIIb/IIIa receptor. Patients taking platelet inhibitors will display increased bleeding time due to the inhibition of platelet aggregation; however, their coagulation parameters, including PT, PTT, and INR should remain normal as these drugs do not interfere with coagulation.
Member Drugs