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Physiologic Neonatal Jaundice

  • Physiologic Neonatal Jaundice is a fairly common disorder characterized by a mild unconjugated hyperbilirubinemia in neonates a few days after birth. Levels of enzymes required for bilirubin conjugation are low immediately after birth (See: Heme Degradation) and require a couple of weeks to rise. Consequently, in some newborns, levels of unconjugated bilirubin rise enough to produce jaundice which typically subsides without any intervention and without any clinically significant consequences.