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Pauci-immune Glomerulonephritis

  • Pauci-immune glomerulonephritis is a pattern of glomerulonephritis characterized by an absence of clear glomerular antibody deposits and usually occurs as a component of several ANCA-positive vasculitides such as Wegener Granulomatosis or microscopic polyangiitis. Although pauci-immune glomerulonephritis is not always present in those with Wegener Granulomatosis and microscopic polyangiitis, when it does occur, patients display signs and symptoms of nephritic syndrome (i.e. Hematuria, pyuria, secondary hypertension, oliguria, and azotemia).
  • Light Microscopy: A variety of histopathologies may be present but frequently rapidly progressive glomerulonephritis is observed
  • Immunofluorescence: Notable absence of immune deposits in the glomerulus