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Neuraminidase Inhibitors

Mechanism of Action
  • As discussed in Influenza Virus, successful release of newly-generated virions from infected cell requires the enzymatic action of the Influenza envelope protein neuraminidase which cleaves sialic acid. Neuraminidase Inhibitors are sialic acid analogs which inhibit viral neuraminidase and by doing so slow spread of virus within the host by preventing effective release of newly synthesized virions.
Member Drugs and Adverse Effects
  • Oseltamivir: Administered orally and may result in some GI upset
  • Zanamivir: Delivered by inhaler and has lead to serious respiratory complications in those with COPD