Metronidazole (Flagyl)
| Overview |
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- Metronidazole (Flagyl) is an antimicrobial that displays a unique spectrum of activity against certain protozoa and bacteria that can proliferate in anaerobic conditions.
| Mechanism of Action |
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- Protozoa and bacteria growing under anaerobic conditions possess proteins in their electron transport chain which can donate an electron to Metronidazole. This electron transfer to Metronidazole generates a highly reactive species which can damage multiple microbial biomolecules and ultimately result in death.
| Adverse Effects |
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- Metronidazole is well-tolerated and the most common adverse effect is GI upset. Patients often report a sensation of metallic taste in their mouths.