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  • Lymphomas are a loose grouping of white cell neoplasms characterized by a lymphocytic origin and a tendency to involve solid organs, especially the lymph nodes, spleen, and liver, rather than the peripheral blood. However, in many cases neoplastic cells eventually spill into the peripheral blood and display a mixed lymphoma/leukemia picture.
  • Lymphomas are divided into two basic clinical categories, Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL), reflecting the unique histopathology and clinical treatment of Hodgkin Lymphoma. In contrast, NHLs represent a very diverse grouping of entities and their sub-division into distinct diseases has been historically challenging with frequent re-evaluations as further pathological, clinical, genetic, and immunohistochemical knowledge progresses.