Flucytosine
| Overview |
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- Flucytosine is an orally-available antifungal used for treating systemic mycoses.
| Mechanism of Action |
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- Flucytosine is activated by fungal enzymes and enters the nucleic acid synthetic pathway, generating a Thymidine analog. This analog can either inhibit normal Thymidine synthesis or can be incorporated during RNA synthesis, resulting in improper termination of the growing RNA chain.
| Adverse Effects |
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- Pancytopenia: May result due to reversible bone marrow suppression
- Nonspecific Effects: These include nausea, vomiting, and diarrhea