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Cutaneous T-cell Lymphoma

  • Cutaneous T-cell Lymphoma (CTCL) is a rare subtype of Non-Hodgkin Lymphoma composed of neoplastic T-cells that localize to the skin. CTCLs can present with a wide variety of cutaneous morphologies but typically display slowly progressive development of localized or diffusely-distributed scaling papules and plaques that expand over years. Pruritis is a common feature and the lesions are often confused with eczema in the early stages. In the late stage, neoplastic cells can spill out of the skin and into lymph nodes and visceral organs. A variety of morphological subtypes exist with "Mycosis Fungoides" and "Sezary Syndrome" being the most common.