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Coagulative Necrosis

  • Coagulative Necrosis is a particular morphological pattern of necrosis. It is caused when protein denaturation is the predominant necrotic process and there is only a small contribution from enzymatic degradation. It is thought that sharp reductions in cellular pH during coagulative necrotic processes may inactivate lytic enzymes before they can induce significant structural damage. Because enzymatic degradation plays a small role, tissues that undergo coagulative necrosis often display preserved tissue architecture for days or weeks following cell death.