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Budd-Chiarri Syndrome

  • Budd-Chiarri Syndrome is a type of posthepatic circulatory disorder that results from acute or chronic obstruction of the hepatic vein or its branches. Obstruction of these vessels is usually due to thrombosis which can be caused by a number of etiologies.
Common Etiologies
  • Hypercoagulable States:
    • Although rare, hyperocagulable states can precipitate hepatic vein thrombosis. Polycythemia Vera, oral contraceptive usage, or pregnancy are particularly notable.
  • Hepatocellular Carcinoma:
    • Is a risk factor for Budd-Chiarri Syndrome.
Clinical Consequences
  • Ascites may occur even though the obstruction is post-hepatic as backup of blood can result in portal hypertension and thus ascites. Hepatomegaly and abdominal pain occur due to congestion of blood within the liver. Jaundice, Elevated serum aminotransferases, and eventually hepatic failure occur due progressive hepatic dysfunction.