Dobutamine

Overview
  • Dobutamine is a synthetic direct adrenergic agonist with complex pharmacological properties; however, in general dobutamine can be thought of as a selective beta1 receptor agonist with potent cardio-stimulatory properties in the absence of significant vascular effects.
Pharmacological Effects
  • Stimulation of beta1 receptors by dobutamine results in profound increases in contractility and thus cardiac output. For complex pharmacological reasons, dobutamine does not change heart rate significantly. Additionally, dobutamine has relatively little effect on the vasculature.
Therapeutic Uses
  • Dobutamine is primarily used in contexts of cardiogenic shock in order to boost contractility and cardiac output. Because it has relatively little effect on heart rate and does not increase the systemic vascular resistance, and thus afterload, it is able to boost cardiac output without generating significantly increased cardiac oxygen demand.