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Diffuse Large B-cell Lymphoma (DLBCL)

  • Diffuse Large B-cell Lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin Lymphoma (NHL) and accounts for roughly 25% of all NHLs. Recent studies have shown that DLBCL likely represents a genetically heterogeneous group of disorders with newly-described subtypes displaying different prognoses that are now managed differently.
Morphology and Immunophenotype
  • As the name suggests, DLBCLs are histologically characterized by large cells with large nuclei. Their immunophenotype suggests that they arise from mature, activated B-cells.
Clinical Consequences
  • DLBCLs are aggressive neoplasms that primarily present in the elderly although up to 20% do occur in children. They typically present as a rapidly enlarging painless lymph node although extranodal involvement is also possible.