- Wiskott-Aldrich Syndrome is caused by an inactivating mutation in the 'Wiskott-Aldrich Syndrome Protein' gene. How this mutation is connected to the diverse clinical consequences is not currently well-understood.
- Thrombocytopenia which usually leads to a variety of bleeding disorders
- Infection Susceptibility: Recurrent infections, especially to encapsulated bacteria as Humoral Immunity cannot generate antibodies to polysaccharide antigens
- In most cases, patients do not survive childhood