- Whipple Disease is caused by systemic infection with the gram positive organism Tropheryma whippelii; however, the subsequent pathogenesis of this condition is cryptic.
- Characteristically, the small intestine mucosa is filled with macrophages laden with PAS-positive granules that contain the partially digested organisms. These microbe-filled macrophages are also present in heart valves and joints causing additional functional derangements at these locations.
- GI System: Steatorrhea and weight loss
- Heart: Cardiac abnormalities
- Joint: Arthritis
- Antibiotics are highly effective.