Ribavirin

Overview
  • Ribavirin is a broadbased antiviral agent and can inhibit replication of a variety of DNA and RNA viruses. Clinically, ribavirin is used in combination with Pegylated Interferon for treatment of chronic Hepatitis C Virus infection. Severe RSV infections are also frequently treated with ribavirin.
Mechanism of Action
  • The detailed mechanism of action of ribavarin is not completely understood. The drug is nucleoside analog and is tri-phosphorylated to a nucleotide analog by host cell enzymes in the nucleotide synthetic pathway. The tri-phosphorylated species of the drug appears to interfere with multiple aspects of viral RNA synthesis and maturation.
Adverse Effects
  • Anemia due to bone marrow suppression