Reye Syndrome

Overview
  • Reye Syndrome is a rare pediatric syndrome characterized by development of fatty liver and hepatic encephalopathy.
Pathogenesis
  • Reye syndrome is extremely rare but is reported to occur in children a few days to weeks following an acute viral infection during which aspirin has been administered. The correlation of pathology with viral infection and aspirin use has led to the contra-indication of administering Aspirin to children in the context of an acute illness which may be viral in origin.
Morphology
  • The liver displays microvesicular steatosis. Some cerebral edema may occur in the brain.
Clinical Consequences
  • Rapid hepatic failure with hyperbilirubinemia and elevated serum aminotransferases. Encephalopathy resulting in rapid neurological deterioration.