Rapidly Progressive Glomerulonephritis (RPGN)

Overview
  • Rapidly Progressive Glomerulonephritis (RPGN) is a histopathological morphology of glomerulonephritis which can be caused by a wide variety of diseases. RPGN is characterized by the extremely rapid development of the signs and symptoms traditional nephritic syndrome.
Morphology
  • RPGN is histopathologically characterized by the presence of cellular "Crescents" within Bowman's space and is thus sometimes termed "Crescentic Glomerulonephritis". These crescents are composed of a variety of cells but include inflammatory cells
  • During the course of disease they may enlarge to completely obliterate the glomerulus.
Clinical Consequences
Etiology and Pathogenesis