- Quinolines are a family of structurally-related antimalarials that are based on the "Quinoline" ring. These compounds have a long history of use in treatment of malaria.
- The mechanism of action of quinolines is still not completely understood. However, it appears that quinolines may interfere with plasmodial sequestration of heme released during the organisms voracious metabolism of erythrocyte hemoglobin. Heme appears to be toxic to plasmodia and the organisms polymerize the molecule into the compound "Hemozoin" to avert toxicity. Quinolones concentrate in the organism's food vacuole where hemoglobin is metabolized and appear to interfere with heme polymerization, and thus cause build up of this toxic molecule and ultimately protozoal death.