Pyrimethamine

Overview
  • Pyrimethamine is used as a therapy for both malaria and Toxoplasma gondii. It is an anti-metabolite and which specifically inhibits protozoal synthesis of tetrahydro-folic acid which key cofactor required for nucleic acid synthesis. At high dosages, pyrimethamine treatment can cause macrocytic anemia due to inhibition of human tetrahydro-folic acid synthesis.