Pseudo-Hypoparathyroidism

Overview
  • Pseudo-Hypoparathyroidism manifests as a clinical syndrome similar to hypoparathyroidism but is the result of a distinct etiopathogenesis (Hence "Pseudo").
Etiology
  • Pseudo-Hypoparathyroidism is caused by deficient tissue responsiveness to secreted Parathyroid Hormone (PTH) due to defects in signaling proteins downstream of the membrane receptor for PTH. Consequently, target tissues can not respond to secreted PTH hormones and this manifests clinically similar to an absence of PTH although levels of the hormone are typically excessive due to defective negative feedback on hormone secretion.
Clinical Consequences
  • Pseudo-Hypoparathyroidism presents identically to hypoparathyroidism as the syndrome of hypocalcemia along with hyperphosphatemia.