- Primary Syphilis describes the first set of physical lesions that appear following infection with Treponema pallidum.
- The lesion of Primary Syphilis typically appears 2-6 weeks after inoculation and disappears completely 4-6 weeks later.
- The lesion of primary syphilis is described as a "Chancre" and begins as a firm papule at the site of inoculation. The lesion erodes over time resulting in a well-defined ulcer with a clean base. The lesion is characteristically painless and usually occurs on the genitals, specifically the penis in men, and on the labia or the cervix in women. Along with the lesion, painless non-supperative regional lymphadenopathy, usually of the inguinal lymph nodes occurs.