- Metronidazole (Flagyl) is an antimicrobial that displays a unique spectrum of activity against certain protozoa and bacteria that can proliferate in anaerobic conditions.
- Protozoa and bacteria growing under anaerobic conditions possess proteins in their electron transport chain which can donate an electron to Metronidazole. This electron transfer to Metronidazole generates a highly reactive species which can damage multiple microbial biomolecules and ultimately result in death.
- Metronidazole is well-tolerated and the most common adverse effect is GI upset. Patients often report a sensation of metallic taste in their mouths.