Macrolides

Overview
  • The macrolides are a class of structurally-related Bacterial Ribosome Inhibitors. These drugs are often used in patients who cannot tolerate penicillins due to allergies. These drugs are well-tolerated and result in relatively few adverse effects.
Mechanism of Action
  • Macrolides bind to the 50S subunit of the bacterial ribosome.
Adverse Effects
  • GI System: Can cause some gastric irritation resulting in epigastric pain
  • Biliary Tree: Can result in cholestasis and thus jaundice
Member Drugs
  • Azithromycin
  • Clarithromycin
  • Erythromycin