Lymphoblastic Lymphoma

  • Lymphoblastic Lymphomas are a histological subtype of Non-Hodgkin Lymphoma and represent neoplasms of early-stage hematopoietic progenitors of lymphocytes, termed "lymphoblasts".
  • In this sense, lymphoblastic lymphomas are essentially the same disease entity as Acute Lymphocytic Leukemias (ALLs) the major difference being that lymphoblastic lymphomas primarily involve the lymphoid organs with less involvement in the peripheral blood and bone marrow. However, while ALLs tend to originate from B-cell precursors, lymphoblastic lymphomas tend to originate more frequently from T-cells precursors and are thus often termed, "Precursor T-cell Lymphomas".
  • Lymphoblastic Lymphomas typically present as a mediastinal mass and like ALLs are highly aggressive neoplasms that usually present in children.