Lamivudine

Overview
  • Lamivudine is a nucleoside analog that is used for treatment of both HIV and Chronic Hepatitis B Virus infections. It is generally well-tolerated with few adverse effects at therapeutic doses.
Mechanism of Action
  • As explained more fully in HIV NRTIs, Lamivudine is a nucleoside analog which is tri-phosphorylated to a nucleotide-like species by cellular enzymes of the host nucleotide synthetic pathway. It is then inappropriately incorporated by HIV reverse transcriptase and HBV DNA Polymerase during replication of the viral genome. Incorporation of the tri-phosphate form of Lamivudine results in chain termination and thus inhibits viral replication in host cells.