Isoniazid

Overview
Mechanism of Action
  • Isoniazid inhibits the enzymatic synthesis of mycolic acid in the M. tuberculosis cell wall.
Adverse Effects
  • Hepatotoxicity:
    • This is an idiosyncratic adverse effect and is potentially fatal. There is increased incidence of hepatotoxicity in alcoholics.
  • Peripheral Neuropathy:
    • Isoniazid appears to increase urinary excretion of Vitamin B6 and may result in a syndrome of deficiency which manifests primarily as a peripheral neuropathy.