• Hyperplasia refers to an increase in the number of cells within a tissue due to mitosis. It is important to note that hyperplastic cells still maintain strict regulatory control of their cell cycle. Consequently, when the stimuli which induce hyperplasia are removed, cells will terminate their divisions. In contrast, cell division in the absence of stimuli is considered neoplasia.
  • Hyperplasia can be induced by specific hormonal stimuli, increased functional demand on the tissue, or by injury to the tissue. When due to tissue injury, surviving cells often enter mitosis to replace those lost due to cell death. Use the search function for specific examples.