- Fibromyalgia is a chronic musculoskeletal pain syndrome characterized by widespread, multi-focal areas of soft tissue tenderness. The disease is much more common in women. While the etiology is currently unclear, it appears that fibromyalgia is not a disorder of immunity but rather may be a consequence of hypersensitivity to the sensation of pain. Patients complain of widespread soft-tissue pain characteristically on both sides of the body as well as above and below the waist. Pain is typically accompanied by fatigue as well as cognitive and mood disturbances. There is a high co-morbidity psychiatric disorders such as depression and anxiety disorders.