Diffuse Cortical Necrosis

Overview

Diffuse Cortical Necrosis is a rare disorder characterized by wide-spread necrosis of the renal cortex occurring in the context of major hemodynamic collapse combined with Disseminated Intravascular Coagulation (DIC).

Morphology

Grossly: Bilateral and diffuse necrosis in both kidneys largely limited to the renal cortex.
Histologically: Coagulative necrosis of cortical tissue is observed along with thromboses throughout the glomerular capillaries.

Pathogenesis

The pathogenesis of this condition is not well-understood but probably involves diffuse thrombotic plugging of glomerular capillaries together with hemodynamic collapse, thus resulting in rapid and severe ischemia to the renal cortex.

Etiologies

Diffuse Cortical Necrosis can be observed in the context of placental abruption, DIC, or major surgeries.