Diffuse Cortical Necrosis
Overview |
---|
- Diffuse Cortical Necrosis is a rare disorder characterized by wide-spread necrosis of the renal cortex occurring in the context of major hemodynamic collapse combined with Disseminated Intravascular Coagulation (DIC).
Morphology |
---|
- Grossly: Bilateral and diffuse necrosis in both kidneys largely limited to the renal cortex.
- Histologically: Coagulative necrosis of cortical tissue is observed along with thromboses throughout the glomerular capillaries.
Pathogenesis |
---|
- The pathogenesis of this condition is not well-understood but probably involves diffuse thrombotic plugging of glomerular capillaries together with hemodynamic collapse, thus resulting in rapid and severe ischemia to the renal cortex.
Etiologies |
---|
- Diffuse Cortical Necrosis can be observed in the context of placental abruption, DIC, or major surgeries.