Diffuse Cortical Necrosis
- Grossly: Bilateral and diffuse necrosis in both kidneys largely limited to the renal cortex.
- Histologically: Coagulative necrosis of cortical tissue is observed along with thromboses throughout the glomerular capillaries.
- The pathogenesis of this condition is not well-understood but probably involves diffuse thrombotic plugging of glomerular capillaries together with hemodynamic collapse, thus resulting in rapid and severe ischemia to the renal cortex.
- Diffuse Cortical Necrosis can be observed in the context of placental abruption, DIC, or major surgeries.