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Diffuse Cortical Necrosis

  • Grossly: Bilateral and diffuse necrosis in both kidneys largely limited to the renal cortex.
  • Histologically: Coagulative necrosis of cortical tissue is observed along with thromboses throughout the glomerular capillaries.
  • The pathogenesis of this condition is not well-understood but probably involves diffuse thrombotic plugging of glomerular capillaries together with hemodynamic collapse, thus resulting in rapid and severe ischemia to the renal cortex.
  • Diffuse Cortical Necrosis can be observed in the context of placental abruption, DIC, or major surgeries.