Diffuse Cortical Necrosis
| Overview |
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- Diffuse Cortical Necrosis is a rare disorder characterized by wide-spread necrosis of the renal cortex occurring in the context of major hemodynamic collapse combined with Disseminated Intravascular Coagulation (DIC).
| Morphology |
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- Grossly: Bilateral and diffuse necrosis in both kidneys largely limited to the renal cortex.
- Histologically: Coagulative necrosis of cortical tissue is observed along with thromboses throughout the glomerular capillaries.
| Pathogenesis |
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- The pathogenesis of this condition is not well-understood but probably involves diffuse thrombotic plugging of glomerular capillaries together with hemodynamic collapse, thus resulting in rapid and severe ischemia to the renal cortex.
| Etiologies |
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- Diffuse Cortical Necrosis can be observed in the context of placental abruption, DIC, or major surgeries.