Clindamycin

Overview
  • Clindamycin has a narrow antibacterial range but is particularly effective against anaeorbes and has activity against Methicillin-resistant S. aureus (MRSA). It is also frequently used to reduce exotoxin synthesis by certain gram positive bacteria. Its mechanism of action is that of inhibiting the 50S bacterial ribosome.
  • The primary adverse effect of Clindamycin is development of "Pseudomembranous Colitis" caused by intestinal toxin production by Clostridium difficile