Beta2 Receptor
| Overview |
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- The Beta2 Adrenergic Receptor is a generally activating G-protein Coupled Receptor (GPCR) that binds the catecholamines norepinephrine and epinephrine.
| Mechanism of Action |
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- The Beta2 Receptor is a generally excitatory GPCR connected to the Gs G-protein. Briefly, following receptor stimulation, activated Gs leads to stimulation of adenylyl cyclase and the generation of cAMP which induces further downstream signaling responsible for the physiological actions of beta2 receptor activation.
| Physiological Anatomy |
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- Overview
- The physiological actions of beta2 receptors center around relaxation of smooth muscle and modulation hepatic metabolism.
- Bronchioles
- Activation of Beta2 Receptors within bronchiolar sooth muscle leads to bronchodilation and thus reduced airflow resistance within the lung.
- Uterus
- Activation of Beta2 Receptors within the uterine smooth muscle leads to uterine relaxation
- Vasculature
- Activation of Beta2 Receptors within the vascular smooth muscle leads to vasodilation and thus reduced systemic vascular resistance.
- Hepatic Glucose Metabolism
- Activation of Beta2 Receptors within the liver stimulates glycogenolysis and gluconeogenesis, together increasing blood glucose concentration.