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Beta1 Receptor

  • The Beta1 Adrenergic Receptor is a generally activating G-protein Coupled Receptor (GPCR) that binds the catecholamines norepinephrine and epinephrine. The most important effects of beta1 receptors are stimulation of the heart although they also enhance renal salt retention and stimulation of lipolysis.
Mechanism of Action
  • The Beta1 Receptor is a generally excitatory GPCR connected to the Gs G-protein. Briefly, following receptor stimulation, activated Gs leads to stimulation of adenylyl cyclase and the generation of intracellular cAMP which induces further downstream signaling responsible for the physiological actions of beta1 receptor activation.
Physiological Anatomy
  • Heart
    • Activation of cardiac Beta1 Receptors leads to increased heart rate and contractility, thus boosting cardiac output (Discussed further in Autonomic Cardiac Regulation.
  • Kidneys
    • Activation of Beta1 Receptors in the kidneys stimulates release of renin and may also directly increase renal salt and water resorption as discussed further in SNS - Renal Effects
  • Adipose Tissue
    • Activation of Beta1 receptors in aadipocytes leads to enhanced lipolysis.