Aminoglycosides

Overview
  • Aminoglycosides are a class of structurally-related Bacterial Ribosome Inhibitors. Their diffusion across the peptidoglycan cell wall of bacteria is significantly enhanced when a Penicillin-class antibiotic is also administered. Consequently, the antibacterial potency of beta-lactams and aminoglycosides are synergistic.
Mechanism of Action
  • Aminoglycosides bind the 30S subunit of the bacterial ribosome.
Adverse Effects
  • Overview: The adverse effects of aminoglycosides are fairly predictable and only occur at high doses. Consequently, blood levels in patients are generally closely monitored to ensure safe concentrations
  • Ototoxicity: Can affect both the vestibula and cochlea resulting in hearing loss and vertigo
  • Nephrotoxicity: Can result in acute tubular necrosis
  • Paralysis: Occurs due to decreased activity at the neuromuscular junction
Member Drugs
  • Amikacin
  • Gentamicin
  • Neomycin
  • Streptomycin
  • Tobramycin